A SIMPLE ROUTE TO CHIRAL FERROCENYL ALCOHOLS

被引：68

作者：

WRIGHT, J ^{[1
]}

FRAMBES, L ^{[1
]}

REEVES, P ^{[1
]}

机构：

[1] ABILENE CHRISTIAN UNIV,DEPT CHEM,ABILENE,TX 79699

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1994年 / 476卷 / 02期

关键词：

IRON; FERROCENE DERIVATIVES; CHIRALITY; ENANTIOSELECTIVE SYNTHESIS; BORANE;

D O I：

10.1016/0022-328X(94)87084-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A chiral B-methylated oxazaborolidine, complexed with borane, has been shown to be a highly effective enantioselective reducing agent for a variety of acyl ferrocenes. The resulting chiral ferrocenyl alcohols are obtained in high overall yields and with very high optical purity (greater than 95% enantiomeric excess). Reactions times are less than 1 h and isolation and purification of the chiral alcohols is accomplished readily. The chiral material used in the synthesis of the optically-active oxazaborolidine can be recovered at the end of the reaction.

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页码：215 / 217

页数：3

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