SYNTHESIS OF NEW STABLE FLUOROPROSTACYCLIN ANALOGS WITH POTENT ANTIANGINAL ACTIVITY

被引：17

作者：

ASAI, T ^{[1
]}

MORIZAWA, Y ^{[1
]}

SHIMADA, T ^{[1
]}

NAKAYAMA, T ^{[1
]}

URUSHIHARA, M ^{[1
]}

MATSUMURA, Y ^{[1
]}

YASUDA, A ^{[1
]}

机构：

[1] ASAHI GLASS CO LTD, RES CTR, KANAGAWA KU, YOKOHAMA, KANAGAWA 221, JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02217-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17,20-dimethylprostacyclins (1, 2) with potent and long-lasting anti-anginal activities has been achieved via three-component coupling reaction and stereospecific fluorination.

引用

页码：273 / 276

页数：4

共 21 条

[1] [Anonymous], 1993, ORGANOFLUORINE COMPO
[2] PROSTAGLANDIN CHEMISTRY .20. SYNTHESIS OF CHEMICALLY STABLE PROSTACYCLIN ANALOGS
BANNAI, K
TORU, T
OBA, T
TANAKA, T
OKAMURA, N
WATANABE, K
HAZATO, A
KUROZUMI, S
[J]. TETRAHEDRON, 1983, 39 (22) : 3807 - 3819
[3] BEZUGLOV VV, 1984, DOKL AKAD NAUK SSSR+, V277, P1400
[4] SYNTHESIS OF THERAPEUTICALLY USEFUL PROSTAGLANDIN AND PROSTACYCLIN ANALOGS
COLLINS, PW
DJURIC, SW
[J]. CHEMICAL REVIEWS, 1993, 93 (04) : 1533 - 1564
[5] Filler R., 1982, BIOMEDICAL ASPECTS F
[6] 10,10-DIFLUORO-13-DEHYDROPROSTACYCLIN - CHEMICALLY AND METABOLICALLY STABILIZED POTENT PROSTACYCLIN
FRIED, J
MITRA, DK
NAGARAJAN, M
MEHROTRA, MM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (03) : 234 - 237
[7] Hudlicky M., 1988, ORG REACTIONS, V35, P513, DOI DOI 10.1002/0471264180.0R035.03
[8] MARKOVSK.LN, 1973, SYNTHESIS-STUTTGART, P787
[9] PROSTAGLANDIN SYNTHESES BY 3-COMPONENT COUPLING
NOYORI, R
SUZUKI, M
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (11): : 847 - 876
[10] Noyori R., 1994, ASYMMETRIC CATALYSIS

← 1 2 3 →