LINKAGE ANALYSES OF THE MODY3 LOCUS ON CHROMOSOME 12Q WITH LATE-ONSET NIDDM

被引:32
作者
LESAGE, S
HANI, EH
PHILIPPI, A
VAXILLAIRE, M
HAGER, J
PASSA, P
DEMENAIS, F
FROGUEL, P
VIONNET, N
机构
[1] CTR ETUD POLYMORPHISME HUMAIN,INST PASTEUR,CNRS,EP10,F-75010 PARIS,FRANCE
[2] HOP ST LOUIS,SERV ENDOCRINOL,PARIS,FRANCE
[3] HOP ST LOUIS,INSERM,U358,PARIS,FRANCE
关键词
D O I
10.2337/diabetes.44.10.1243
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder, Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM, We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families, To evaluate if this gene is also implicated in late-onset NIDDM, we performed Linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM, Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population, However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.
引用
收藏
页码:1243 / 1247
页数:5
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