DIGESTION AND FERMENTATION OF PROTEINS IN RATS FED KERATIN, ALBUMIN, COOKED CASEIN AND ANTIBIOTICS

被引:9
作者
CORPET, DE
BELLIER, R
PETROWITSCH, S
VIGOUROUX, Y
机构
[1] INRA, XENOBIOT LAB, F-31931 TOULOUSE, FRANCE
[2] INRA, RECH CUNICOLES STN, F-31326 CASTANET TOLOSAN, FRANCE
来源
REPRODUCTION NUTRITION DEVELOPMENT | 1994年 / 34卷 / 01期
关键词
PROTEIN; COOKED CASEIN; ANTIBIOTIC; FERMENTATION; DIGESTION;
D O I
10.1051/rnd:19940106
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dietary cooked casein promotes colon cancer in rats. We speculated and tested the hypothesis that cooking reduces the digestibility of casein, and increases the yield of bacterial metabolites, which are potential promoters of cancer. We investigated dietary means to manipulate nitrogen transfer and fermentation in the caecum. The caecal digestion of casein (cooked or not), keratin (hydrolysed or not) and bovine serum albumin (oxidized or not) was measured in rats. Protein fermentation was estimated by assaying caecal ammonia and branched-chain fatty acids. Keratin and cooked casein were digested to a very low extent, and were poorly fermented. Rats given cooked casein had 2-3 times more ammonia in their caecum than animals given the other proteins. Antibiotics (bacitracin, chlortetracycline, neomycin and spiramycin, at either 20 and 80 mu g/ml water) decreased caecal ammonia in rats eating cooked casein, with spiramycin being most efficient. These data support the hypothesis given above, and provide ways to manipulate caecal ammonia.
引用
收藏
页码:57 / 64
页数:8
相关论文
共 25 条
[1]   FECAL AMMONIA IN PATIENTS WITH ADENOMATOUS POLYPS AND CANCER OF THE COLON [J].
CLAUSEN, MR ;
MORTENSEN, PB .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1992, 18 (02) :175-180
[2]  
CLINTON SK, 1988, CANCER RES, V48, P3035
[3]  
CORPET DE, 1990, CANCER RES, V50, P6955
[4]  
Cummings J. H, 1991, LARGE INTESTINE PHYS, P51
[5]  
CUMMINGS JH, 1987, CANCER SURV, V6, P601
[6]   UREA CYCLING AND AMMONIA ABSORPTION INVIVO IN THE DIGESTIVE-TRACT OF THE RAT [J].
DEMIGNE, C ;
REMESY, C .
ANNALES DE BIOLOGIE ANIMALE BIOCHIMIE BIOPHYSIQUE, 1979, 19 (NB3) :929-935
[7]   MEAT, COOKING METHODS AND COLORECTAL-CANCER - A CASE-REFERENT STUDY IN STOCKHOLM [J].
DEVERDIER, MG ;
HAGMAN, U ;
PETERS, RK ;
STEINECK, G ;
OVERVIK, E .
INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (04) :520-525
[8]   THE CAUSES OF CANCER - QUANTITATIVE ESTIMATES OF AVOIDABLE RISKS OF CANCER IN THE UNITED-STATES TODAY [J].
DOLL, R ;
PETO, R .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1981, 66 (06) :1191-+
[9]  
FRANCOIS AC, 1968, NUTR DIETA, V10, P35
[10]   SIGNIFICANCE OF MICROFLORA IN PROTEOLYSIS IN THE COLON [J].
GIBSON, SAW ;
MCFARLAN, C ;
HAY, S ;
MACFARLANE, GT .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1989, 55 (03) :679-683