AZATHIOPRINE-INDUCED PULMONARY HEMORRHAGE IN A CHILD AFTER RENAL-TRANSPLANTATION

被引：8

作者：

REFABERT, L ^{[1
]}

SINNASSAMY, P ^{[1
]}

LEROY, B ^{[1
]}

FAUROUX, B ^{[1
]}

DEBLIC, J ^{[1
]}

BENSMAN, A ^{[1
]}

机构：

[1] HOP ENFANTS ARMAND TROUSSEAU,SERV NEPHROL,PARIS,FRANCE

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 04期

关键词：

AZATHIOPRINE; PULMONARY HEMORRHAGE; RENAL TRANSPLANT;

D O I：

10.1007/BF00866729

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a case of azathioprine-induced haemorrhagic alveolitis, in a 14-year-old boy, after renal transplantation. On day 25 the patient developed haemoptysis, fever and hypoxaemia, Chest X-ray showed diffuse reticulo-nodular shadows in both lung fields, Bronchoalveolar lavage samples were haemorrhagic and demonstrated a relative neutrophilia and a mild lymphocytosis, with a normal CD4/CD8 ratio. Azathioprine was discontinued on day 26. The patient required mechanical ventilation for 4 days. A positive leucocyte migration inhibition test and the recurrence of the symptoms after a second short course of azathioprine therapy suggested a cell-mediated mechanism. This patient is, to our knowledge, the first child to suffer from azathioprine-induced pulmonary haemorrhage.

引用

页码：470 / 473

页数：4

共 23 条

[1]

Lockshin M.D., Kagen L.I., Meningitic reaction after azathioprine, N Engl J Med, 286, pp. 1321-1322, (1972)

[2]

Farthing M.J.D., Coxon A.Y., Sheaff P.C., Polyneuritis associated with azathioprine therapy, BMJ, 280, (1980)

[3]

Bosh F.H., Meinders A.E., General malaise, high fever and arthralgias as rare side effects of azathioprine, Ned Tijdschr Geneeskd, 129, pp. 1593-1595, (1985)

[4]

Cunningham T., Barraclough D., Muirden K., Azathioprine-induced shock, BMJ, 283, pp. 823-824, (1981)

[5]

Major G.A.C., Moore P., Acute hypersensitivity with profound circulatory collapse following exposure to azathioprine, Aust N Z J Med, 14, pp. 371-372, (1984)

[6]

Rosenthal E., Azathioprine shock, Postgrad Med J, 62, pp. 677-678, (1986)

[7]

Rubin G., Baume P., Vaudenberg, Azathioprine and acute restrictive lung disease, Aust N Z J Med, 2, pp. 272-274, (1972)

[8]

Weissenburger D.D., Interstitial pneumonitis associated with azathioprine therapy, Am J Clin Pathol, 69, pp. 181-185, (1978)

[9]

Krowka M.J., Breuer R.I., Kehoe T.J., Azathioprine-associated pulmonary dysfunction, Chest, 83, pp. 696-698, (1983)

[10]

Carmichael D.J.S., Hamilton D.V., Evans D.B., Stovin P.G.I., Calne R.Y., Interstitial pneumonitis secondary to azathioprine in a renal transplant patient, Thorax, 38, pp. 951-952, (1983)

← 1 2 3 →