THE EFFECT OF SELENIUM ADDED CARDIOPLEGIA IN GUINEA-PIGS

被引：9

作者：

SONCUL, H ^{[1
]}

TATLICAN, O ^{[1
]}

HALIT, V ^{[1
]}

OZ, E ^{[1
]}

SINCI, V ^{[1
]}

SALMAN, E ^{[1
]}

GOKGOZ, L ^{[1
]}

TURKOZKAN, N ^{[1
]}

ERSOZ, A ^{[1
]}

机构：

[1] GAZI UNIV,FAC MED,DEPT BIOCHEM,ANKARA,TURKEY

来源：

GENERAL PHARMACOLOGY | 1994年 / 25卷 / 07期

关键词：

SELENIUM; CARDIOPLEGIA; ISCHEMIC INJURY;

D O I：

10.1016/0306-3623(94)90179-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The aim of the study was to determine the effect of selenium added cardioplegic solutions on postischemic myocardial recovery. 2. The hearts were mounted on Langendorf perfusion apparatus and perfused with Krebs-Henseleit solution. The hearts were arrested by one of the following cardioplegic solutions; (a) K+ 20 mmol/l (control group); (b) K+ 20 mmol/l + selenium 10(-3) mol/l (experimental group). After 20 min of normo-thermic ischemia the hearts were reperfused by the same buffer. 3. Postischemic percentage changes of heart rate, contractile force and heart work were compared between the groups. 4. Addition of selenium to the cardioplegic solution significantly decreased the postischemic myocardial injury.

引用

页码：1493 / 1497

页数：5

共 11 条

[1]

Burk R F, 1978, World Rev Nutr Diet, V30, P88

[2]

JOHANSEN JV, 1988, ANN THORAC SURG, V45, P319

[3]

MANASHE P, 1988, CIRCULATION S3, V74, P138

[4] ISCHEMIC PRECONDITIONING IS NOT MEDIATED BY FREE-RADICALS IN THE ISOLATED RABBIT HEART [J].