O2 TRANSPORT IN ANESTHETIZED DOGS IN HYPOXIA WITH O2 UPTAKE INCREASED BY 2 - 4-DINITROPHENOL

Pulmonary gas exchange and O2 transport by circulation were studied in anesthetized dogs breathing 11 % O2 in Na at increased levels of metabolism produced by administration of 2:4-dini-trophenol (up to 20 mg/kg). The O2 uptake could be increased up to 7.7 times the control value. The effective alveolar ventilation increased closely proportionally to V̇CO2 and V̇O2, so that the arterial PCO2 and PO2 remained largely constant. The cardiac output increased up to 2.7 times. The dogs died when PO2 in mixed venous blood had fallen below 10 mm Hg. The results are compared with those obtained on dogs running on the treadmill in hypoxia. © 1969.