ATOMIC-STRUCTURE OF A FRAGMENT OF HUMAN CD4 CONTAINING 2 IMMUNOGLOBULIN-LIKE DOMAINS

被引:554
作者
WANG, JH
YAN, YW
GARRETT, TPJ
LIU, JH
RODGERS, DW
GARLICK, RL
TARR, GE
HUSAIN, Y
REINHERZ, EL
HARRISON, SC
机构
[1] UPJOHN CO, KALAMAZOO, MI 49007 USA
[2] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA
[3] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, IMMUNOL LAB, BOSTON, MA 02115 USA
[4] HOWARD HUGHES MED INST, CAMBRIDGE, MA 02138 USA
关键词
D O I
10.1038/348411a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The structure of an N-terminal fragment of CD4 has been determined to 2.4 Å resolution. It has two tightly abutting domains connected by a continuous β strand. Both have the immunoglobulin fold, but domain 2 has a truncated β barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocom-patibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface. © 1990 Nature Publishing Group.
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页码:411 / 418
页数:8
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