ATENOLOL DETERMINATION BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND FLUORESCENCE DETECTION

被引：61

作者：

YEE, YG ^{[1
]}

RUBIN, P ^{[1
]}

BLASCHKE, TF ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL,STANFORD,CA 94305

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 171卷 / APR期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0021-9673(01)95315-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic procedure using a fluorescence detector for the analysis of atenolol in plasma and whole blood is described. It employs a simple and rapid method of preparation. Atenolol and metoprolol as the internal standard are chromatographed as ion pairs with heptanesulfonic acid. The method is sensitive and reproducible with accurate detection at concentrations as low as 2 ng/ml in whole blood and plasma, and a coefficient of variation of 4.7% over the range 2 ng/ml to 1000 ng/ml. © 1979.

引用

页码：357 / 362

页数：6

共 5 条

[1] AMERY A, 1977, CLIN PHARMACOL THER, V21, P691
[2] BARRETT AM, 1973, BRIT J PHARMACOL, V48, P340
[3] SIMPLE SPECTROPHOTOFLUOROMETRIC METHOD FOR MEASUREMENT OF ICI 66082 IN PLASMA AND URINE
KAYE, CM
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1974, 1 (01) : 84 - 86
[4] GAS-CHROMATOGRAPHIC DETERMINATION OF ATENOLOL IN BIOLOGICAL SAMPLES
SCALES, B
COPSEY, PB
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (06) : 430 - 433
[5] RAPID-DETERMINATION OF ATENOLOL IN HUMAN-PLASMA AND URINE BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY
WEDDLE, OH
AMICK, EN
MASON, WD
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (07) : 1033 - 1035

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