OLIVANIC ACIDS, A FAMILY OF BETA-LACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORY PROPERTIES PRODUCED BY STREPTOMYCES SPECIES .2. ISOLATION AND CHARACTERIZATION OF THE OLIVANIC ACIDS MM-4550, MM-13902 AND MM-17880 FROM STREPTOMYCES-OLIVACEUS

被引：84

作者：

HOOD, JD

BOX, SJ

VERRALL, MS

机构：

[1] Beecham Pharmaceuticals Research Division, Brockham Park, Betchworth

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 04期

关键词：

D O I：

10.7164/antibiotics.32.295

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The olivanic acids MM 4550, MM 13902 and MM 17880 are members of a new family of β-lactam antibiotics. An isolation and purification process utilising ion-pair extraction and ion-exchange chromatography is described and the metabolites are characterised by physico-chemical and biological properties. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：295 / 304

页数：10

共 16 条

[1] ALBERSSCHONBERG G, 1976, 16TH INT C ANT AG CH
[2] NATURALLY-OCCURRING BETA-LACTAMASE INHIBITORS WITH ANTIBACTERIAL ACTIVITY
BROWN, AG
BUTTERWORTH, D
COLE, M
HANSCOMB, G
HOOD, JD
READING, C
[J]. JOURNAL OF ANTIBIOTICS, 1976, 29 (06) : 668 - 669
[3] STRUCTURES OF OLIVANIC ACID-DERIVATIVES MM 4550 AND MM 13902 - 2 NEW, FUSED BETA-LACTAMS ISOLATED FROM STREPTOMYCES OLIVACEUS
BROWN, AG
CORBETT, DF
EGLINGTON, AJ
HOWARTH, TT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1977, (15) : 523 - 525
[4] OLIVANIC ACIDS, A FAMILY OF BETA-LACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORY PROPERTIES PRODUCED BY STREPTOMYCES SPECIES .1. DETECTION, PROPERTIES AND FERMENTATION STUDIES
BUTTERWORTH, D
COLE, M
HANSCOMB, G
ROLINSON, GN
[J]. JOURNAL OF ANTIBIOTICS, 1979, 32 (04) : 287 - 294
[5] CASSIDY PJ, 1977, 17TH INT C ANT AG CH
[6] CLARKE HT, 1949, CHEM PENICILLIN, P209
[7] STRUCTURE ELUCIDATION OF MM-17880, A NEW FUSED BETA-LACTAM ANTIBIOTIC ISOLATED FROM STREPTOMYCES-OLIVACEUS - MILD BETA-LACTAM DEGRADATION REACTION
CORBETT, DF
EGLINGTON, AJ
HOWARTH, TT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1977, (24) : 953 - 954
[8] KAHAN JS, 1976, 16TH INT C ANT AG CH
[9] KAHAN JS, 1977, Patent No. 2652681
[10] KROPP H, 1976, 16TH INT C ANT AG CH

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