A NEW BABY-SPACER DEVICE FOR AEROSOLIZED BRONCHODILATOR ADMINISTRATION IN INFANTS WITH BRONCHOPULMONARY DISEASE

被引:30
作者
KRAEMER, R
BIRRER, P
MODELSKA, K
AEBISCHER, CC
SCHONI, MH
机构
[1] Paediatric Respiratory Research Group, Department of Paediatrics, University of Berne, Inselspital, Berne
关键词
BRONCHODILATORS; INFANTS; BRONCHOPULMONARY DISEASE; BABY-SPACER DEVICE; BABYHALER;
D O I
10.1007/BF02073894
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The response of salbutamol (Ventolin, Glaxo), topically administered from a metered dose inhaler (MDI) through a new baby-spacer-device (Babyhaler, Glaxo) was studied in 14 infants (8 wheezy infants, 3 infants with cystic fibrosis and 3 infants after respiratory distress syndrome), age 2.9-18.8 months. Changes in thoracic gas volume (TGV) as an estimate of pulmonary hyperinflation and changes in airway conductance (Gaw) as an estimate of bronchial obstruction were assessed by whole-body plethysmography. After baseline measurements, 1 puff of 100-mu-g salbutamol was given repeatedly at 5 min intervals until 600-mu-g have been inhaled and TGV and Gaw were measured after each inhalation at 5, 10, 15, 20, 25 and 30 min. Significant improvement in lung function was achieved in 57.1% of infants after 400-mu-g and in 92.9% of infants after 600-mu-g salbutamol. The study shows usefulness of bronchodilator treatment in infants with bronchopulmonary disease by a system with a MDI and baby-spacer-device. However a special dose-time relationship must be respected.
引用
收藏
页码:57 / 60
页数:4
相关论文
共 28 条
[1]   RELATIONSHIP BETWEEN AIRWAY RESISTANCE, AIRWAY CONDUCTANCE AND LUNG VOLUME IN SUBJECTS OF DIFFERENT AGE AND BODY SIZE [J].
BRISCOE, WA ;
DUBOIS, AB .
JOURNAL OF CLINICAL INVESTIGATION, 1958, 37 (09) :1279-1285
[2]   RELIABLE SALBUTAMOL ADMINISTRATION IN 6-MONTH-OLD TO 36-MONTH-OLD CHILDREN BY MEANS OF A METERED DOSE INHALER AND AEROCHAMBER WITH MASK [J].
CONNER, WT ;
DOLOVICH, MB ;
FRAME, RA ;
NEWHOUSE, MT .
PEDIATRIC PULMONOLOGY, 1989, 6 (04) :263-267
[3]   METHOD OF USING PRESSURIZED AEROSOLS [J].
CONNOLLY, CK .
BRITISH MEDICAL JOURNAL, 1975, 3 (5974) :21-21
[4]  
DAVIES DS, 1975, POSTGRAD MED J, V51, P69
[5]  
DETROYER A, 1978, AM REV RESPIR DIS, V118, P987
[6]   RAPID PLETHYSMOGRAPHIC METHOD FOR MEASURING THORACIC GAS VOLUME - COMPARISON WITH A NITROGEN WASHOUT METHOD FOR MEASURING FUNCTIONAL RESIDUAL CAPACITY IN NORMAL SUBJECTS [J].
DUBOIS, AB ;
BOTELHO, SY ;
BEDELL, GN ;
MARSHALL, R ;
COMROE, JH .
JOURNAL OF CLINICAL INVESTIGATION, 1956, 35 (03) :322-326
[7]   USE OF A SPECIAL INHALER ATTACHMENT IN ASTHMATIC-CHILDREN [J].
ELLULMICALLEF, R ;
MOREN, F ;
WETTERLIN, K ;
HIDINGER, KC .
THORAX, 1980, 35 (08) :620-623
[8]   DEPOSITION OF AEROSOLS IN PULMONARY-DISEASE [J].
GOLDBERG, IS ;
LOURENCO, RV .
ARCHIVES OF INTERNAL MEDICINE, 1973, 131 (01) :88-91
[9]   EFFECT OF AN EXTENSION TUBE ON THE BRONCHODILATOR EFFICACY OF TERBUTALINE DELIVERED FROM A METERED DOSE INHALER [J].
GOMM, SA ;
KEANEY, NP ;
WINSEY, NJP ;
STRETTON, TB .
THORAX, 1980, 35 (07) :552-556
[10]   SHORT-TIME RESPONSE CHARACTERISTICS OF SALBUTAMOL IN INFANTS WITH BRONCHOPULMONARY DISEASES [J].
KRAEMER, R ;
BIRRER, P ;
SENNHAUSER, FH ;
SCHONI, MH .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 34 (04) :339-342