PHOSPHOROTHIOATE OLIGONUCLEOTIDES AS POTENTIAL ANTIVIRAL COMPOUNDS AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS AND HERPES VIRUSES

被引：11

作者：

CHENG, YC

GAO, WY

HAN, FS

机构：

[1] Department of Pharmacology, Yale University School of Medicine, New Haven

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319108046443

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorothioate oligonucleotides (S-oligos) with and without sequence specificity complementary to viral genes were found to have activities against human immunodeficiency virus (HIV) and herpes simplex virus type 2. The potential usage of S-oligo as an antisense molecule and as antiviral compound is discussed.

引用

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页码：155 / 166

页数：12

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