NEW PEPTIDE BORONIC ACID INHIBITORS OF THROMBIN

被引：25

作者：

ELGENDY, S

DEADMAN, J

PATEL, G

GREEN, D

CHINO, N

GOODWIN, CA

SCULLY, MF

KAKKAR, VV

CLAESON, G

机构：

[1] Thrombosis Research Institute, London, SW3 6LR, Emmanuel Kaye Building, Manresa Road, Chelsea

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)74691-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic peptides with the sequence D-Phe-Pro-boroAa containing a P1 aminoboronic acid with a neutral side chain show good thrombin inhibition as well as selectivity for thrombin, and have no serious side effect on blood pressure.

引用

页码：4209 / 4212

页数：4

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