A CASE OF FATAL INFECTIOUS-MONONUCLEOSIS PRESENTING WITH FULMINANT HEPATIC-FAILURE ASSOCIATED WITH AN EXTENSIVE CD8-POSITIVE LYMPHOCYTE INFILTRATION IN THE LIVER

被引：24

作者：

TAZAWA, Y

NISHINOMIYA, F

NOGUCHI, H

TAKADA, G

TSUCHIYA, S

SUMAZAKI, R

TAKITA, H

KANNO, H

NOSE, M

KONNO, T

机构：

[1] TSUKUBA UNIV, SCH MED, DEPT PEDIAT, TSUKUBA, JAPAN

[2] TOHOKU UNIV, SCH MED, DEPT PATHOL, SENDAI, MIYAGI 980, JAPAN

[3] TOHOKU UNIV, DEV AGING & CANC RES INST, DEPT PEDIAT, SENDAI, MIYAGI 980, JAPAN

来源：

HUMAN PATHOLOGY | 1993年 / 24卷 / 10期

关键词：

INFECTIOUS MONONUCLEOSIS; FULMINANT HEPATIC FAILURE; EPSTEIN-BARR VIRUS; KARYORRHEXIS; CD8-POSITIVE LYMPHOCYTE;

D O I：

10.1016/0046-8177(93)90195-M

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We describe a fatal case of infectious mononucleosis presenting with fulminant hepatic failure associated with extensive CD8-positive lymphocyte infiltration and diffuse karyorrhexis in the liver. Immunohistochemical analysis of mononuclear cells showed that Leu-2a (CD8)-positive lymphocytes were heavily distributed in the portal areas and the sinusoidal spaces, but Leu-3a (CD4)-, Leu-14 (CD22)-, or My 4 (CD14)-positive cells were undetectable in sections of the liver. Southern blot hybridization studies disclosed the presence of Epstein-Barr virus DNA fragments in the liver tissue. The unusual pathologic and immunologic responses observed in this case could not simply be explained by severe Epstein-Barr virus infection. Some superimposed factors should be considered. © 1993.

引用

页码：1135 / 1139

页数：5

共 25 条

[1] USE OF CLONED PROBES TO DETECT EPSTEIN-BARR VIRAL-DNA IN TISSUES OF PATIENTS WITH NEOPLASTIC AND LYMPHOPROLIFERATIVE DISEASES [J].

ANDIMAN, W ;

GRADOVILLE, L ;

HESTON, L ;

NEYDORFF, R ;

SAVAGE, ME ;

KITCHINGMAN, G ;

SHEDD, D ;

MILLER, G .

JOURNAL OF INFECTIOUS DISEASES, 1983, 148 (06) :967-977

[2]

ANDIMAN WA, 1979, J PEDIATR-US, V95, P171, DOI 10.1016/S0022-3476(79)80646-0

[3]

COLBY TV, 1982, GASTROENTEROLOGY, V82, P339

[4] EPSTEIN-BARR VIRUS-INFECTION IN A CHILD WITH ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

FACKLER, JC ;

NAGEL, JE ;

ADLER, WH ;

MILDVAN, PT ;

AMBINDER, RF .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1985, 139 (10) :1000-1004

[5] X-LINKED LYMPHOPROLIFERATIVE SYNDROME REGISTRY REPORT [J].

HAMILTON, JK ;

PAQUIN, LA ;

SULLIVAN, JL ;

MAURER, HS ;

CRUZI, FG ;

PROVISOR, AJ ;

STEUBER, CP ;

HAWKINS, E ;

YAWN, D ;

CORNET, JA ;

CLAUSEN, K ;

FINKELSTEIN, GZ ;

LANDING, B ;

GRUNNET, M ;

PURTILO, DT .

JOURNAL OF PEDIATRICS, 1980, 96 (04) :669-673

[6]

HORWITZ CA, 1980, CLIN CHEM, V26, P243

[7] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].

HSU, SM ;

RAINE, L ;

FANGER, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580

[8]

LLOYD-STILL J D, 1986, Pediatric Pathology, V5, P337

[9] HEPATITIS IN FATAL INFECTIOUS-MONONUCLEOSIS [J].

MARKIN, RS ;

LINDER, J ;

ZUERLEIN, K ;

MROCZEK, E ;

GRIERSON, HL ;

BRICHACEK, B ;

PURTILO, DT .

GASTROENTEROLOGY, 1987, 93 (06) :1210-1217

[10]

MILLER DJ, 1976, NEW ENGL J MED, V295, P450

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