A PATHWAY FOR DISULFIDE BOND FORMATION INVIVO

被引：392

作者：

BARDWELL, JCA

LEE, JO

JANDER, G

MARTIN, N

BELIN, D

BECKWITH, J

机构：

[1] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA

[2] UNIV GENEVA, CTR MED, DEPT PATHOL, CH-1211 GENEVA 4, SWITZERLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 03期

关键词：

D O I：

10.1073/pnas.90.3.1038

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Protein disulfide bond formation in Escherichia coli requires the periplasmic protein DsbA. We describe here mutations in the gene for a second protein, DsbB, which is also necessary for disulfide bond formation. Evidence suggests that DsbB may act by reoxidizing DsbA, thereby regenerating its ability to donate its disulfide bond to target proteins. We propose that DsbB, an integral membrane protein, may be involved in transducing redox potential across the cytoplasmic membrane.

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页码：1038 / 1042

页数：5

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