SPECIFIC TOLERANCE ACROSS A DISCORDANT XENOGENEIC TRANSPLANTATION BARRIER

被引：102

作者：

LEE, LA

GRITSCH, HA

SERGIO, JJ

ARN, JS

GLASER, RM

SABLINSKI, T

SACHS, DH

SYKES, M

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP EAST,SCH MED,TRANSPLANTAT BIOL RES CTR,BOSTON,MA 02129

[2] BIOTRANSPLANT INC,BOSTON,MA 02129

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 23期

关键词：

D O I：

10.1073/pnas.91.23.10864

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Successful induction of tolerance across disparate (discordant) species barriers could overcome the organ shortage that presently limits clinical transplantation. We demonstrate here that xenogeneic swine thymic transplants can induce tolerance to swine antigens in mice, while positively selecting functional host CD4(+) T cells. Immunologically normal C57BL/10 mice were thymectomized and depleted of T and natural killer cells; then they received transplants of fetal pig thymus and liver fragments. Mature mouse CD4(+) T cells developed in the pig thymus grafts and migrated to the periphery. Swine grafts grew markedly and no anti-pig IgG response was produced. Mixed lymphocyte reactions confirmed that the new T cells were functional and were tolerant to pig antigens.

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页码：10864 / 10867

页数：4

相关论文

共 12 条

[1] THE MHC MOLECULE I-E IS NECESSARY BUT NOT SUFFICIENT FOR THE CLONAL DELETION OF V-BETA-11-BEARING T-CELLS [J].

BILL, J ;

KANAGAWA, O ;

WOODLAND, DL ;

PALMER, E .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) :1405-1419

[2] STRONG T-CELL TOLERANCE IN PARENT-]F1 BONE-MARROW CHIMERAS PREPARED WITH SUPRALETHAL IRRADIATION - EVIDENCE FOR CLONAL DELETION AND ANERGY [J].

GAO, EK ;

LO, D ;

SPRENT, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :1101-1121

[3] THE IMPORTANCE OF NONIMMUNE FACTORS IN RECONSTITUTION BY DISCORDANT XENOGENEIC HEMATOPOIETIC-CELLS [J].

GRITSCH, HA ;

GLASER, RM ;

EMERY, DW ;

LEE, LA ;

SMITH, CV ;

SABLINSKI, T ;

ARN, JS ;

SACHS, DH ;

SYKES, M .

TRANSPLANTATION, 1994, 57 (06) :906-917

[4] SPECIES-RESTRICTED INTERACTIONS BETWEEN CD8 AND THE ALPHA-3 DOMAIN OF CLASS-I INFLUENCE THE MAGNITUDE OF THE XENOGENEIC RESPONSE [J].

IRWIN, MJ ;

HEATH, WR ;

SHERMAN, LA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1091-1101

[5] THE CONCURRENT MATURATION OF MOUSE AND HUMAN THYMOCYTES IN HUMAN FETAL THYMUS IMPLANTED IN NIH-BEIGE-NUDE-XID MICE IS ASSOCIATED WITH THE RECONSTITUTION OF THE MURINE IMMUNE-SYSTEM [J].

KOLLMANN, TR ;

GOLDSTEIN, MM ;

GOLDSTEIN, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (03) :821-832

[6] TOLERANCE OF CD8+ T-CELLS DEVELOPING IN PARENT -] F1-CHIMERAS PREPARED WITH SUPRALETHAL IRRADIATION - STEP-WISE INDUCTION OF TOLERANCE IN THE INTRATHYMIC AND EXTRATHYMIC ENVIRONMENTS [J].

KOSAKA, H ;

SPRENT, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :367-378

[7]

LUCAS PJ, 1990, J IMMUNOL, V144, P4548

[8] EVIDENCE THAT MULTIPLE DEFECTS IN CELL-SURFACE MOLECULE INTERACTIONS ACROSS SPECIES-DIFFERENCES ARE RESPONSIBLE FOR DIMINISHED XENOGENEIC T-CELL RESPONSES [J].

MOSES, RD ;

WINN, HJ ;

AUCHINCLOSS, H .

TRANSPLANTATION, 1992, 53 (01) :203-209

[9] XENOGENEIC PROLIFERATION AND LYMPHOKINE PRODUCTION ARE DEPENDENT ON CD4+ HELPER T-CELLS AND SELF ANTIGEN-PRESENTING CELLS IN THE MOUSE [J].

MOSES, RD ;

PIERSON, RN ;

WINN, HJ ;

AUCHINCLOSS, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (02) :567-575

[10] THYMIC EPITHELIUM TOLERIZES FOR HISTOCOMPATIBILITY ANTIGENS [J].

SALAUN, J ;

BANDEIRA, A ;

KHAZAAL, I ;

CALMAN, F ;

COLTEY, M ;

COUTINHO, A ;

LEDOUARIN, NM .

SCIENCE, 1990, 247 (4949) :1471-1474