UP-REGULATION OF NICOTINIC RECEPTORS FOLLOWING CONTINUOUS-INFUSION OF NICOTINE IS BRAIN-REGION-SPECIFIC

被引：108

作者：

SANDERSON, EM ^{[1
]}

DRASDO, AL ^{[1
]}

MCCREA, K ^{[1
]}

WONNACOTT, S ^{[1
]}

机构：

[1] UNIV BATH,BATH BA2 7AY,AVON,ENGLAND

来源：

BRAIN RESEARCH | 1993年 / 617卷 / 02期

基金：

英国惠康基金;

关键词：

PLASMA NICOTINE; OSMOTIC MINIPUMP; H-3]NICOTINE BINDING SITE; STRIATUM; CORTEX; HIPPOCAMPUS;

D O I：

10.1016/0006-8993(93)91104-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats receiving 4 mg nicotine/kg/day via implanted minipumps sustained plasma nicotine concentrations of 40 ng/ml throughout two weeks of nicotine infusion. Numbers of brain [H-3]nicotine binding sites were increased by about 50% in cortex and hippocampus whereas numbers of [H-3]nicotine binding sites in striatum were unaffected by nicotine treatment at either of the timepoints examined (7, 14 days). Cortical [I-125]alpha-bungarotoxin and [H-3]QNB binding sites were also unchanged. The regional selectivity of nicotinic receptor modulation may reflect the low dose of nicotine used and the mode of administration. The changes observed may be pertinent to the continuous administration of nicotine in man, via transdermal nicotine patches.

引用

页码：349 / 352

页数：4

共 21 条

[1] STABLE ISOTOPE METHOD FOR STUDYING TRANSDERMAL DRUG ABSORPTION - THE NICOTINE PATCH [J].