INCREASED SERUM PROMMP-3 IN INFLAMMATORY ARTHRITIDES - A POTENTIAL INDICATOR OF SYNOVIAL INFLAMMATORY MONOKINE ACTIVITY

被引：67

作者：

TAYLOR, DJ ^{[1
]}

CHEUNG, NT ^{[1
]}

DAWES, PT ^{[1
]}

机构：

[1] HAYWOOD HOSP, STAFFORDSHIRE RHEUMATOL CTR, STOKE ON TRENT ST6 7AG, STAFFS, ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1994年 / 53卷 / 11期

关键词：

D O I：

10.1136/ard.53.11.768

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-To investigate if the increased concentrations of stromelysin (MMP-3) found in the synovial fluid (SF) of patients with various arthritides reflect the concentrations in the circulation. Methods-Using a double antibody ELISA, we have measured proMMP-3 concentrations in sera from these patient groups and in others with a heightened acute phase response (APR) as a result of multiple organ failure. Results-The median serum concentration of proMMP-3 was increased by up to ninefold in the inflammatory arthritides, but not in osteoarthritis or in patients with a heightened APR resulting from a non-chronic inflammatory condition. Conclusion-In chronic inflammatory diseases such as rheumatoid arthritis, serum proMMP-3 may prove to be a more specific indicator of monokine activity than currently available serum markers.

引用

页码：768 / 772

页数：5

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