INHIBITION OF MAMMALIAN RNA-POLYMERASE BY 5,6-DICHLORORIBOFURANOSYLBENZIMIDAZOLE (DRB) AND DRB TRIPHOSPHATE

被引:36
作者
DREYER, C
HAUSEN, P
机构
[1] Max-Planck-Institut für Virusforschung, Abteilung für Zellbiologie
关键词
D O I
10.1093/nar/5.9.3325
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DRB triphosphate inhibits activity of isolated RNA polymerase B, and, to a lesser extent, that of polymerase A. The same holds true for transcription in isolated nuclei. It does not act as an initiation inhibitor. In all cases, high concentrations of DRB triphosphate are required. Cells do not phosphorylate DRB to a measurable extent. hn RNA resistant to DRB is initiated with both ATP and GTP in the presence of the drug. These experiments render the hypothesis unlikely that DRB triphosphate in the cell specifically interferes with the initiation reaction of polymerase B. © 1978 Information Retrieval Limited.
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页码:3325 / 3335
页数:11
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