MOVEMENT-DISORDERS OF AGED RATS - REVERSAL BY DOPAMINE RECEPTOR STIMULATION

被引:189
作者
MARSHALL, JF
BERRIOS, N
机构
[1] Department of Psychobiology, University of California, Irvine
关键词
D O I
10.1126/science.504992
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments in swimming. Compared with young adult rats (3 to 4 months old), the older animals moved their limbs less vigorously and were less successful in keeping their heads above water. The young, but not old, rats maintained a position nearly horizontal to the water surface and planed across it. These movement dysfunctions of aged rats resemble those seen in young adult animals that have sustained injury to brain dopamine-containing neurons. The swimming impairments of the aged rats were reversed by the dopamine receptor stimulant apomorphine and by the biosynthetic precursor of dopamine, L-dopa. Thus, age-related alterations in brain dopaminergic systems may be responsible for some of the movement disturbances associated with senescence. Copyright © 1979 AAAS.
引用
收藏
页码:477 / 479
页数:3
相关论文
共 31 条
[1]   RECEPTOR ACTIVITY AND TURNOVER OF DOPAMINE AND NORADRENALINE AFTER NEUROLEPTICS [J].
ANDEN, NE ;
BUTCHER, SG ;
CORRODI, H ;
FUXE, K ;
UNGERSTEDT, U .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1970, 11 (03) :303-+
[2]  
BARBEAU A, 1961, 7 P INT C NEUR ROM, V2, P925
[3]   INCREASE OF CEREBRAL CATECHOLAMINES CAUSED BY 3,4-DIHYDROXYPHENYLALANINE AFTER INHIBITION OF PERIPHERAL DECARBOXYLASE [J].
BARTHOLINI, G ;
BURKARD, WP ;
PLETSCHER, A ;
BATES, HM .
NATURE, 1967, 215 (5103) :852-+
[4]   OCCURRENCE AND LOCALIZATION OF CATECHOL AMINES IN HUMAN BRAIN [J].
BERTLER, A .
ACTA PHYSIOLOGICA SCANDINAVICA, 1961, 51 (2-3) :97-&
[5]  
BIRKMAYER W, 1961, Wien Klin Wochenschr, V73, P787
[6]   INFLUENCE OF AGE AND TIME INTERVAL BETWEEN DEATH AND AUTOPSY ON DOPAMINE AND 3-METHOXYTYRAMINE LEVELS IN HUMAN BASAL GANGLIA [J].
CARLSSON, A ;
WINBLAD, B .
JOURNAL OF NEURAL TRANSMISSION, 1976, 38 (3-4) :271-276
[7]   PARKINSON DISEASE TREATED WITH A SUSPECTED DOPAMINE RECEPTOR AGONIST [J].
CHASE, TN ;
WOODS, AC ;
GLAUBIGER, GA .
ARCHIVES OF NEUROLOGY, 1974, 30 (05) :383-386
[8]   AROMATIC AMINO ACIDS AND MODIFICATION OF PARKINSONISM [J].
COTZIAS, GC ;
VANWOERT, MH ;
SCHIFFER, LM .
NEW ENGLAND JOURNAL OF MEDICINE, 1967, 276 (07) :374-&
[9]   SIMILARITIES BETWEEN NEUROLOGIC EFFECTS OF L-DOPA AND OF APOMORPHINE [J].
COTZIAS, GC ;
PAPAVASILIOU, PS ;
FEHLING, C ;
KAUFMAN, B ;
MENA, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1970, 282 (01) :31-+
[10]  
EVARTS E, DOPAMINERGIC ERGOT D