WATER-SOLUBLE BENZODIAZEPINES WITH AGONISTIC AND ANTAGONISTIC ACTIONS ON GABA-INDUCED INHIBITION IN CULTURED HYPOTHALAMUS

被引：11

作者：

GELLER, HM

机构：

[1] Department of Pharmacology, C.M.D.N.J. - Retgers Medical School, Piscataway, NJ 08854

来源：

NEUROSCIENCE LETTERS | 1979年 / 15卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96132-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interaction of two benzodiazepine compounds, flurazepam (a sedative) and RO 5-3663 (a convulsant), with amino acid depressions of spontaneous neuronal activity in hypothalamic tissue cultures has been examined. Flurazepam selectively potentiated, GABA-induced inhibition, while RO 5-3663 selectively reduced GABA-induced inhibition. These results are interpreted as supporting the presence of two types of benzodiazepine binding sites in the brain which would modulate endogenous GABA-mediated inhibition and behavior. © 1979.

引用

收藏

页码：313 / 318

页数：6

相关论文

共 22 条

[1] PHARMACOLOGICAL CHARACTERIZATION OF BENZODIAZEPINE RECEPTORS IN BRAIN [J].

BRAESTRUP, C ;

SQUIRES, RF .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 48 (03) :263-270

[2] SPECIFIC BENZODIAZEPINE RECEPTORS IN RAT-BRAIN CHARACTERIZED BY HIGH-AFFINITY [DIAZEPAM-H-3] BINDING - (AFFINITY BINDING DIAZEPAM ANXIOLYTIC ACTIVITY BRAIN MEMBRANES REGIONAL DISTRIBUTION) [J].

BRAESTRUP, C ;

SQUIRES, RF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3805-3809

[3] CENTRAL ACTIONS OF BENZODIAZEPINES [J].

CURTIS, DR ;

LODGE, D ;

JOHNSTON, GAR ;

BRAND, SJ .

BRAIN RESEARCH, 1976, 118 (02) :344-347

[4]

FRANCO S, 1978, FED PROC, V37, P613

[5] DIAZEPAM AND CHLORDIAZEPOXIDE - POWERFUL GABA ANTAGONISTS IN EXPLANTS OF RAT CEREBELLUM [J].

GAHWILER, BH .

BRAIN RESEARCH, 1976, 107 (01) :176-179

[6] BENZODIAZEPINES - POTENTIATION OF A GABA INHIBITORY RESPONSE IN DORSAL RAPHE NUCLEUS [J].

GALLAGER, DW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 49 (02) :133-143

[7] BENZODIAZEPINES AND CENTRAL INHIBITORY MECHANISMS [J].

GELLER, HM ;

TAYLOR, DA ;

HOFFER, BJ .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 304 (02) :81-88

[8] PHASIC DISCHARGE OF NEURONS IN LONG-TERM CULTURES OF TUBERAL HYPOTHALAMUS [J].

GELLER, HM .

BRAIN RESEARCH, 1975, 93 (03) :511-515

[9]

GREENBERG DA, 1978, MOL PHARMACOL, V14, P38

[10] ENHANCEMENT OF GABA-MEDIATED POSTSYNAPTIC INHIBITION IN CULTURED MAMMALIAN SPINAL-CORD NEURONS - COMMON-MODE OF ANTICONVULSANT ACTION [J].

MACDONALD, RL ;

BARKER, JL .

BRAIN RESEARCH, 1979, 167 (02) :323-336