HUMAN ALPHA-TUMOR-NECROSIS-FACTOR DOES NOT DAMAGE CULTURES CONTAINING RAT SCHWANN-CELLS AND SENSORY NEURONS

被引：22

作者：

MITHEN, FA

COLBURN, S

BIRCHEM, R

机构：

[1] Department of Veterans Affairs, John Cochran Medical Center St. Louis, MO

[2] St. Louis University School of Medicine St. Louis, MO

来源：

NEUROSCIENCE RESEARCH | 1990年 / 9卷 / 01期

关键词：

A23187; Guillain-Barré; syndrome; Myelin sheath; Peripheral nerve disease; Schwann cells; Tissue culture; Tumor necrosis factor;

D O I：

10.1016/0168-0102(90)90046-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of recombinant human alpha tumor necrosis factor (alpha-TNF) were compared with those of cytotoxic serum from patients with the acute Guillain-Barré syndrome (GBS) in myelinated cultures containing only rat Schwann cells and dorsal root ganglion neurons. Alpha-TNF did not damage rat peripheral nervous system tissue in culture. These observations suggest that alpha-TNF is not responsible for the cytotoxic activity of acute GBS serum in culture. © 1990.

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页码：59 / 63

页数：5

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