SYNTHESIS OF A LACTOSE-SUBSTITUTED POLY(L-GLUTAMATE)

被引：6

作者：

KOBAYASHI, K ^{[1
]}

ZHOU, SH ^{[1
]}

SUMITOMO, H ^{[1
]}

OKADA, M ^{[1
]}

AKAIKE, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,FAC LIFE SCI & TECHNOL,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

来源：

KOBUNSHI RONBUNSHU | 1991年 / 48卷 / 04期

关键词：

LACTOSE-CARRYING POLY(L-GLUTAMIC ACID); BIOMEDICAL MATERIALS; RECOGNITION SIGNAL; CELLS; OLIGOSACCHARIDES; POLYMERIZATION; POLYPEPTIDE;

D O I：

10.1295/koron.48.253

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The reducing end of lactose was oxidized and reacted with an excess amount of 1,4-butanediamine to give N-(4-aminobutyl)-O-beta-D-galactopyranosyl-(1-->4)-D-gluconamide. The side-chain carboxyl group of poly(L-glutamic acid) was activated with N-hydroxysuccinimide in the presence of N,N'-dicyclohexylcarbodiimide. Amidation between the activated polypeptide and the aminobutylated lactose derivative gave lactose-carrying poly(L-glutamate) whose degree of substitution was 60%.

引用

页码：253 / 256

页数：4

共 14 条

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