IS AMYLOIDOGENESIS DURING ALZHEIMERS-DISEASE DUE TO AN IL-1-/IL-6-MEDIATED ACUTE PHASE RESPONSE IN THE BRAIN

被引：248

作者：

VANDENABEELE, P

FIERS, W

机构：

[1] Laboratory of Molecular Biology, State University, B-9000 Gent

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 07期

关键词：

D O I：

10.1016/0167-5699(91)90032-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alzheimer's disease is characterized by the presence of amyloid plaques in the brain, which comprise mainly beta-amyloid peptide and alpha-1-antichymotrypsin. Here, Peter Vandenabeele and Walter Fiers advance the hypothesis that this amyloidogenesis results from an IL-1-/IL-6-mediated acute phase reaction in the brain. They propose possible intracerebral sources of cytokines and acute phase proteins in microglia, astrocytes, neurons and cells of the choroid plexus.

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页码：217 / 219

页数：3

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