PREPARATIVE SEPARATION AND ANALYSIS OF THE ENANTIOMERS OF [H-3] ABBOTT-69992, AN HIV ANTIINFECTIVE NUCLEOSIDE, BY LIGAND-EXCHANGE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：12

作者：

THOMAS, SB

SURBER, BW

机构：

[1] Drug Metabolism Department, Abbott Laboratories, Abbott Park, IL 60064-3500

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 586卷 / 02期

关键词：

D O I：

10.1016/0021-9673(91)85131-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Several chiral stationary phases (CSPs) were examined to separate the enantiomers of A-69992, a chiral HIV anti-infective nucleoside. The only CSP found to be effective was Nucleosil Chiral-1, a ligand-exchange CSP, which was used to prepare microgram amounts of the enantiomers of high optical purity. This appears to be the first separation of the enantiomers of a nucleoside by chiral high-performance liquid chromatography.

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页码：265 / 270

页数：6

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