EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE

被引：7

作者：

BALDWIN, JE ^{[1
]}

FIELD, RA ^{[1
]}

SCHOFIELD, CJ ^{[1
]}

机构：

[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 21期

关键词：

D O I：

10.1039/c39910001531

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incubation of [O-18(2)]valine with purified ACV synthetase from Cephalosporium acremonium gave exclusive incorporation of a single O-18 label into delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV), consistent with the formation of a covalent valinoyl-ACV synthetase complex.

引用

页码：1531 / 1532

页数：2

共 9 条

[1] [Anonymous], BIOCH PEPTIDE ANTIBI
[2] ISOLATION AND PARTIAL CHARACTERIZATION OF ACV SYNTHETASE FROM CEPHALOSPORIUM-ACREMONIUM AND STREPTOMYCES-CLAVULIGERUS - EVIDENCE FOR THE PRESENCE OF PHOSPHOPANTOTHENATE IN ACV SYNTHETASE
BALDWIN, JE
BIRD, JW
FIELD, RA
OCALLAGHAN, NM
SCHOFIELD, CJ
WILLIS, AC
[J]. JOURNAL OF ANTIBIOTICS, 1991, 44 (02) : 241 - 248
[3] THE BIOSYNTHESIS OF PENICILLINS AND CEPHALOSPORINS
BALDWIN, JE
ABRAHAM, E
[J]. NATURAL PRODUCT REPORTS, 1988, 5 (02) : 129 - 145
[4] THE FATE OF VALINE-OXYGEN DURING PENICILLIN BIOSYNTHESIS
BALDWIN, JE
ADLINGTON, RM
BIRD, JW
SCHOFIELD, CJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (21) : 1615 - 1616
[5] DELTA-(L-ALPHA-AMINOADIPYL)-L-CYSTEINYL-D-VALINE SYNTHETASE (ACV SYNTHETASE) - A MULTIFUNCTIONAL ENZYME WITH BROAD SUBSTRATE-SPECIFICITY FOR THE SYNTHESIS OF PENICILLIN AND CEPHALOSPORIN PRECURSORS
BANKO, G
DEMAIN, AL
WOLFE, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (09) : 2858 - 2860
[6] PARTIAL ELIMINATION OF VALINE-OXYGEN DURING PENICILLIN BIOSYNTHESIS
DELDERFIELD, JS
MTETWA, E
THOMAS, R
TYOBEKA, TE
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (13) : 650 - 652
[7] ATTEMPTS TO MAP A PROCESS EVOLUTION OF PEPTIDE BIOSYNTHESIS
LIPMANN, F
[J]. SCIENCE, 1971, 173 (4000) : 875 - &
[8] VANLIEMPT H, 1989, J BIOL CHEM, V264, P3680
[9] GRAMICIDIN-S SYNTHETASE - TEMPERATURE-DEPENDENCE AND THERMODYNAMIC PARAMETERS OF SUBSTRATE AMINO-ACID ACTIVATION REACTIONS
VATER, J
MALLOW, N
GERHARDT, S
GADOW, A
KLEINKAUF, H
[J]. BIOCHEMISTRY, 1985, 24 (08) : 2022 - 2027

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