TAXOL - QUANTITATIVE INTERNUCLEAR PROTON-PROTON DISTANCES IN CDCL3 SOLUTION FROM NOE DATA - 2D NMR ROESY BUILDUP RATES AT 500 MHZ

被引：37

作者：

HILTON, BD

CHMURNY, GN

MUSCHIK, GM

机构：

[1] Program Resources, Inc./DynCorp, NCI-Freederick Cancer Research and Development Center, Frederick, Maryland21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 08期

关键词：

D O I：

10.1021/np50086a023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Quantitative nmr internuclear proton-proton distance measurements obtained by observation of the initial buildup rates of nOe's in 2D ROESY spectra of taxol [1) in CDCl3 are reported. A comparison to the X-ray crystal structure of taxotere [2] is made, and the results are discussed in terms of previous studies of structure-activity relationships.

引用

页码：1157 / 1161

页数：5

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