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INCREASED EXPRESSION OF HEAT-SHOCK PROTEIN, TRANSFERRIN, AND BETA-2-MICROGLOBULIN IN ASTROCYTES DURING SCRAPIE
被引:29
作者
:
DIEDRICH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
DIEDRICH, JF
CARP, RI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
CARP, RI
HAASE, AT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
HAASE, AT
机构
:
[1]
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
[2]
NEW YORK STATE INST BASIC RES,DEPT VIROL,STATEN ISL,NY 10314
来源
:
MICROBIAL PATHOGENESIS
|
1993年
/ 15卷
/ 01期
关键词
:
ALZHEIMERS DISEASE;
PRION DISEASE;
ASTROCYTOSIS;
AMYLOID;
NEURODEGENERATION;
D O I
:
10.1006/mpat.1993.1051
中图分类号
:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号
:
100102 ;
摘要
:
Scrapie is a slow infection and neurodegenerative disease of animals characterized pathologically by formation of amyloid, astrocytosis, vacuolation and unjury and death of neurons. Our previous studies of scrapie point to: (i) a critical role for the astrocyte in responding to, and perhaps inadvertently contributing to, the neuropathological manifestations of infection; and (ii), the hypothesis that the astrocyte a executes a programed response to neurological injury analogous to the stress response. The expression of genes encoding tranferrin and β2-microglobulin has been shown to increase during scrapie and we sought in the studies reported here to determine whether this modulated expression would map to astrocytes. We also looked for changes in a heat shock protein that is induced in the stress response. We show that transferrin, β2-microglobulin and heat shock 72 kD protein all increase in astrocytes in the course of infection. We speculate in the discussion on the possible functions of the other proteins in neurodegenerative processes and why these functions so frequently reside in the astrocyte. © 1993 Academic Press.
引用
收藏
页码:1 / 6
页数:6
相关论文
共 21 条
[1]
SERUM-FREE CELL-CULTURE - A UNIFYING APPROACH
[J].
BARNES, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
BARNES, D
;
SATO, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
SATO, G
.
CELL,
1980,
22
(03)
:649
-655
[2]
THE IDENTIFICATION OF NEUROTROPHIC FACTOR AS A TRANSFERRIN
[J].
BEACH, RL
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
BEACH, RL
;
POPIELA, H
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
POPIELA, H
;
FESTOFF, BW
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
FESTOFF, BW
.
FEBS LETTERS,
1983,
156
(01)
:151
-156
[3]
TRANSFERRIN GENE-EXPRESSION VISUALIZED IN OLIGODENDROCYTES OF THE RAT-BRAIN BY USING INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY
[J].
BLOCH, B
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
BLOCH, B
;
POPOVICI, T
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
POPOVICI, T
;
LEVIN, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
LEVIN, MJ
;
TUIL, D
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
TUIL, D
;
KAHN, A
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
KAHN, A
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1985,
82
(19)
:6706
-6710
[4]
A ROLE FOR A 70-KILODATON HEAT-SHOCK PROTEIN IN LYSOSOMAL DEGRADATION OF INTRACELLULAR PROTEINS
[J].
CHIANG, HL
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
CHIANG, HL
;
TERLECKY, SR
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TERLECKY, SR
;
PLANT, CP
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
PLANT, CP
;
DICE, JF
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
DICE, JF
.
SCIENCE,
1989,
246
(4928)
:382
-385
[5]
SCRAPIE-ASSOCIATED PRION PROTEIN ACCUMULATES IN ASTROCYTES DURING SCRAPIE INFECTION
[J].
DIEDRICH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
DIEDRICH, JF
;
BENDHEIM, PE
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
BENDHEIM, PE
;
KIM, YS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
KIM, YS
;
CARP, RI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
CARP, RI
;
HAASE, AT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
HAASE, AT
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1991,
88
(02)
:375
-379
[6]
NEUROPATHOLOGICAL CHANGES IN SCRAPIE AND ALZHEIMERS-DISEASE ARE ASSOCIATED WITH INCREASED EXPRESSION OF APOLIPOPROTEIN-E AND CATHEPSIN-D IN ASTROCYTES
[J].
DIEDRICH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
DIEDRICH, JF
;
MINNIGAN, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
MINNIGAN, H
;
CARP, RI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
CARP, RI
;
WHITAKER, JN
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
WHITAKER, JN
;
RACE, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
RACE, R
;
FREY, W
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
FREY, W
;
HAASE, AT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
HAASE, AT
.
JOURNAL OF VIROLOGY,
1991,
65
(09)
:4759
-4768
[7]
DIEDRICH JF, 1991, SEMIN VIROL, V2, P233
[8]
ISOLATION OF CDNAS OF SCRAPIE-MODULATED RNAS BY SUBTRACTIVE HYBRIDIZATION OF A CDNA LIBRARY
[J].
DUGUID, JR
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
DUGUID, JR
;
ROHWER, RG
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
ROHWER, RG
;
SEED, B
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
SEED, B
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(15)
:5738
-5742
[9]
LIBRARY SUBTRACTION OF INVITRO CDNA LIBRARIES TO IDENTIFY DIFFERENTIALLY EXPRESSED GENES IN SCRAPIE INFECTION
[J].
DUGUID, JR
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
DUGUID, JR
;
DINAUER, MC
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
DINAUER, MC
.
NUCLEIC ACIDS RESEARCH,
1990,
18
(09)
:2789
-2792
[10]
CHANGES IN BRAIN GENE-EXPRESSION SHARED BY SCRAPIE AND ALZHEIMER-DISEASE
[J].
DUGUID, JR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
DUGUID, JR
;
BOHMONT, CW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
BOHMONT, CW
;
LIU, N
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
LIU, N
;
TOURTELLOTTE, WW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
TOURTELLOTTE, WW
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1989,
86
(18)
:7260
-7264
←
1
2
3
→
共 21 条
[1]
SERUM-FREE CELL-CULTURE - A UNIFYING APPROACH
[J].
BARNES, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
BARNES, D
;
SATO, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
SATO, G
.
CELL,
1980,
22
(03)
:649
-655
[2]
THE IDENTIFICATION OF NEUROTROPHIC FACTOR AS A TRANSFERRIN
[J].
BEACH, RL
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
BEACH, RL
;
POPIELA, H
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
POPIELA, H
;
FESTOFF, BW
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
VET ADM MED CTR,NEUROBIOL RES LAB,KANSAS CITY,MO 64128
FESTOFF, BW
.
FEBS LETTERS,
1983,
156
(01)
:151
-156
[3]
TRANSFERRIN GENE-EXPRESSION VISUALIZED IN OLIGODENDROCYTES OF THE RAT-BRAIN BY USING INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY
[J].
BLOCH, B
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
BLOCH, B
;
POPOVICI, T
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
POPOVICI, T
;
LEVIN, MJ
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
LEVIN, MJ
;
TUIL, D
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
TUIL, D
;
KAHN, A
论文数:
0
引用数:
0
h-index:
0
机构:
INSERM,U198,F-25000 BESANCON,FRANCE
KAHN, A
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1985,
82
(19)
:6706
-6710
[4]
A ROLE FOR A 70-KILODATON HEAT-SHOCK PROTEIN IN LYSOSOMAL DEGRADATION OF INTRACELLULAR PROTEINS
[J].
CHIANG, HL
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
CHIANG, HL
;
TERLECKY, SR
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TERLECKY, SR
;
PLANT, CP
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
PLANT, CP
;
DICE, JF
论文数:
0
引用数:
0
h-index:
0
机构:
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
TUFTS UNIV,SCH MED,DEPT PHYSIOL,BOSTON,MA 02111
DICE, JF
.
SCIENCE,
1989,
246
(4928)
:382
-385
[5]
SCRAPIE-ASSOCIATED PRION PROTEIN ACCUMULATES IN ASTROCYTES DURING SCRAPIE INFECTION
[J].
DIEDRICH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
DIEDRICH, JF
;
BENDHEIM, PE
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
BENDHEIM, PE
;
KIM, YS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
KIM, YS
;
CARP, RI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
CARP, RI
;
HAASE, AT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
HAASE, AT
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1991,
88
(02)
:375
-379
[6]
NEUROPATHOLOGICAL CHANGES IN SCRAPIE AND ALZHEIMERS-DISEASE ARE ASSOCIATED WITH INCREASED EXPRESSION OF APOLIPOPROTEIN-E AND CATHEPSIN-D IN ASTROCYTES
[J].
DIEDRICH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
DIEDRICH, JF
;
MINNIGAN, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
MINNIGAN, H
;
CARP, RI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
CARP, RI
;
WHITAKER, JN
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
WHITAKER, JN
;
RACE, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
RACE, R
;
FREY, W
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
FREY, W
;
HAASE, AT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455
HAASE, AT
.
JOURNAL OF VIROLOGY,
1991,
65
(09)
:4759
-4768
[7]
DIEDRICH JF, 1991, SEMIN VIROL, V2, P233
[8]
ISOLATION OF CDNAS OF SCRAPIE-MODULATED RNAS BY SUBTRACTIVE HYBRIDIZATION OF A CDNA LIBRARY
[J].
DUGUID, JR
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
DUGUID, JR
;
ROHWER, RG
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
ROHWER, RG
;
SEED, B
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
SEED, B
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988,
85
(15)
:5738
-5742
[9]
LIBRARY SUBTRACTION OF INVITRO CDNA LIBRARIES TO IDENTIFY DIFFERENTIALLY EXPRESSED GENES IN SCRAPIE INFECTION
[J].
DUGUID, JR
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
DUGUID, JR
;
DINAUER, MC
论文数:
0
引用数:
0
h-index:
0
机构:
BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118
DINAUER, MC
.
NUCLEIC ACIDS RESEARCH,
1990,
18
(09)
:2789
-2792
[10]
CHANGES IN BRAIN GENE-EXPRESSION SHARED BY SCRAPIE AND ALZHEIMER-DISEASE
[J].
DUGUID, JR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
DUGUID, JR
;
BOHMONT, CW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
BOHMONT, CW
;
LIU, N
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
LIU, N
;
TOURTELLOTTE, WW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
TOURTELLOTTE, WW
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1989,
86
(18)
:7260
-7264
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