MUREIDOMYCIN-E AND MUREIDOMYCIN-F, MINOR COMPONENTS OF MUREIDOMYCINS

被引：32

作者：

ISONO, F

SAKAIDA, Y

TAKAHASHI, S

KINOSHITA, T

NAKAMURA, T

INUKAI, M

机构：

[1] SANKYO CO LTD,FERMENTAT RES LABS,1-2-58 HIROMACHI,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,ANALYT & METAB RES LAB,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 08期

关键词：

D O I：

10.7164/antibiotics.46.1203

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mureidomycins (MRDs) E and F were isolated from a culture filtrate of Streptomyces flavidovirens SANK 60486 which produces MRDs A-D. They possessed the same molecular formulae, C39H48N8O12S and very similar UV, IR and NMR spectra, but differed clearly from each other in HPLC profile. From the hydrolysates of MRDs E and F, 8-hydroxy-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid and 6-hydroxy-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid were detected, respectively, which were not-detected from those of MRDs A-D. They showed strong anti-pseudomonal activity but less active than MRD A. MRDs E and F were synthesized from MRD A and formaldehyde through Piclet-Spengler reaction.

引用

页码：1203 / 1207

页数：5

共 12 条

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