RUTHENIUM-CATALYZED HYDRATION OF NITRILES AND TRANSFORMATION OF DELTA-KETONITRILES TO ENE-LACTAMS - TOTAL SYNTHESIS OF (-)-PUMILIOTOXIN-C

被引：88

作者：

MURAHASHI, SI

SASAO, S

SAITO, E

NAOTA, T

机构：

[1] Department of Chemistry, Faculty of Engineering Science, Osaka University, Toyonaka, Osaka, 560, Machikaneyama

来源：

TETRAHEDRON | 1993年 / 49卷 / 39期

关键词：

D O I：

10.1016/S0040-4020(01)81902-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydration of nitriles with 1-2 equivalents of water can be performed efficiently by using RuH2(PPh3)4 catalyst to give the corresponding amides. Under the similar reaction conditions, delta-ketonitriles can be converted into the corresponding ene-lactams, which are versatile synthetic intermediates. The efficiency of the reaction is demonstrated by the short-step synthesis of (-)-pumiliotoxin C.

引用

页码：8805 / 8826

页数：22

共 79 条

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