METABOLIC-ACIDOSIS IN THE ALCOHOLIC - AN EMPHASIS ON INTRACELLULAR EVENTS

The focus of this review will be to examine the subject of metabolic acidosis in the alcoholic, emphasing intracellular events. In this regard, two points shall be highlighted: first, ''metabolic'' aspects of metabolic acidosis and their quantitative implications; and second, we will highlight factors that impact on the severity of intracellular acidosis and the titration of intracellular proteins. This approach should provide a better understanding of the pathophysiology of the metabolic acid-base disorders in these patients, and could indicate where leverage should be exerted in therapy.