INFLUENCES OF URETHANE ANESTHESIA ON INDOMETHACIN-INDUCED GASTRIC-MUCOSAL LESIONS IN RATS - RELATION TO BLOOD-GLUCOSE LEVELS

被引:15
作者
TAKEUCHI, K
NIIDA, H
OHUCHI, T
OKABE, S
机构
[1] From the Department of Applied Pharmacology, Kyoto Pharmaceutical University, Kyoto, 607, Misasagi, Yamashina
关键词
URETHANE; INDOMETHACIN; GASTRIC LESION; MOTILITY BLOOD GLUCOSE;
D O I
10.1007/BF02087687
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Effects of urethane on gastric motility and mucosal ulcerogenic responses induced by indomethacin were investigated in the rat in relation to blood glucose levels (BGL) and compared with those of pentobarbital Na. Urethane (1.25 g/kg) given intraperitoneally, caused a progressive and significant rise in BGL, while pentobarbital (30 mg/kg) given intraperitoneally did not affect BGL. Subcutaneous administration of indomethacin (25 mg/kg) caused high-amplitude gastric contractions and induced hemorrhagic lesions in the stomachs. of conscious rats. These lesions were significantly inhibited by urethane but not pentobarbital. Administration of urethane abolished basal gastric motility and almost completely suppressed the motility responses induced by indomethacin, while pentobarbital did not have much effect on gastric motility under basal and indomethacin-stimulated conditions. Acid secretion was significantly decreased by urethane and increased by pentobarbital. Pretreatment of the animals with yohimbine (5 mg/kg, subcutaneously) but not prazosin (0.5 mg/kg) inhibited the elevation in BGL seen after administration of urethane and allowed resumption both gastric motility and ulcerogenic responses induced by indomethacin, with less change in acid secretion. These results suggest that intraperitoneal administration of urethane prevented indomethacin-induced gastric lesions, probably by inhibiting the enhanced gastric motility response, and this effect may relate to its hyperglycemic action mediated by alpha(2)-adrenoceptors, These findings also provide further evidence to support the importance of gastric motility in the pathogenesis of these lesions.
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页码:2536 / 2542
页数:7
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