NALTREXONE ATTENUATES SELF-INJURIOUS-BEHAVIOR IN MENTALLY-RETARDED SUBJECTS

被引：54

作者：

KARS, H

GLAUDEMANSVANGELDEREN, I

VERHOEVEN, WMA

VANREE, JM

机构：

[1] INST MENTAL RETARDAT,BAARN,NETHERLANDS

[2] STATE UNIV UTRECHT HOSP,DEPT BIOL PSYCHIAT,3511 GV UTRECHT,NETHERLANDS

[3] STATE UNIV UTRECHT,RUDOLF MAGNUS INST PHARMACOL,UTRECHT,NETHERLANDS

来源：

BIOLOGICAL PSYCHIATRY | 1990年 / 27卷 / 07期

关键词：

D O I：

10.1016/0006-3223(90)90589-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of naltrexone on the frequency of self-injurious behavior (SIB) was investigated in 6 male subjects with profound mental retardation. Following a double-blind placebo-controlled crossover design, naltrexone was administered in a dose of 50 mg once daily for 3 consecutive weeks. In 2 of 5 subjects, a significant decrease of SIB frequency could be demonstrated, and in 1, a tendency to a reduction was found. No effect on duration of restrain time was found in 3 subjects. These data suggest that disturbances of the endogenous opioid systems may be involved in the pathophysiology of SIB of certain patients. © 1990.

引用

页码：741 / 746

页数：6

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