ACTION OF AFLATOXIN ON SOME REDOX ENZYMES AND COMPLEXES OF AVIAN LIVER-MITOCHONDRIA

被引：7

作者：

OBIDOA, O ^{[1
]}

OBUNWO, CC ^{[1
]}

机构：

[1] AHMADU BELLO UNIV, DEPT BIOCHEM, ZARIA, NIGERIA

来源：

BIOCHEMICAL MEDICINE | 1979年 / 22卷 / 01期

关键词：

D O I：

10.1016/0006-2944(79)90033-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vitro effect of aflatoxin B1 (AFB1) on the coupling membrane-bound and matrix NAD+-dependent dehydrogenases and electron transport complexes of guinea fowl (Numida meleagris Pearl) liver mitochondria was investigated. Redox-dye measure ments indicated that AFB1 (0.05 - 5 μm) decreased the activities of the membrane-bound dehydrogenases, whereas the matrix enzymes were only inhibited at the highest toxin concentration tested. Spectrophotometric studies of the electron transfer complexes spanning the entire respiratory chain suggest that AFB1 interferes with mitochondrial electron transport by inhibiting succinate dehydrogenase activity and the cytochrome systems. © 1979.

引用

页码：27 / 32

页数：6

共 11 条

[1]

BABABUNMI EA, 1973, 542ND M BIOCH SOC T, P1286

[2]

CHANCE B, 1963, J BIOL CHEM, V238, P418

[3] AFLATOXIN INHIBITION OF RAT-LIVER MITOCHONDRIA [J].

DOHERTY, WP ;

CAMPBELL, TC .

CHEMICO-BIOLOGICAL INTERACTIONS, 1973, 7 (02) :63-77

[4]

DOHERTY WP, 1972, RES COMMUN CHEM PATH, V3, P601

[5]

HOGEBOOM GH, 1949, J BIOL CHEM, V177, P847

[6]

Johnson D., 1967, METH ENZYMOL, VVolume 10, P94, DOI DOI 10.1016/0076-6879(67)10018-9

[7]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[8] AFLATOXIN INHIBITION OF AVIAN HEPATIC MITOCHONDRIA [J].

OBIDOA, O ;

SIDDIQUI, HT .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (04) :547-550

[9]

RAMACHANDRAPAI M, 1975, CHEM-BIOL INTERACT, V10, P123, DOI 10.1016/0009-2797(75)90106-4

[10]

RENDINA G, 1971, EXPT METHODS MODERN, P277

← 1 2 →