DOUBLE-BLIND RANDOMIZED CLINICAL-TRIAL OF A PEPSIN-INHIBITORY PENTAPEPTIDE (PEPSTATIN) IN THE TREATMENT OF DUODENAL-ULCER

被引：15

作者：

BONNEVIE, O ^{[1
]}

SVENDSEN, LB ^{[1
]}

HOLSTCHRISTENSEN, J ^{[1
]}

JOHANSEN, TS ^{[1
]}

SOLTOFT, J ^{[1
]}

CHRISTIANSEN, PM ^{[1
]}

机构：

[1] UNIV COPENHAGEN,HVIDOVRE HOSP,SURG DEPT GASTROENTEROL,DK-2650 HVIDOVRE,DENMARK

来源：

GUT | 1979年 / 20卷 / 07期

关键词：

D O I：

10.1136/gut.20.7.624

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In a double-blind randomised clinical trial a specific inhibition of peptic activity with a pentapeptide, pepstatin, has no significant advantage over placebo in the ulcer healing and symptomatology of duodenal ulcer. Thus, the inhibition of pepsin in human gastric juice does not appear to have a major influence on the healing of duodenal ulcer.

引用

页码：624 / 628

页数：5

共 18 条

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GRIBBLE, RJN
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[9] MECHANISM OF INHIBITION OF PEPSIN BY PEPSTATIN
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TAKEUCHI, T
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MORISHIMA, H
[J]. JOURNAL OF ANTIBIOTICS, 1972, 25 (04) : 251 - +
[10] LANDECKER KD, 1976, GASTROENTEROLOGY, V71, P723

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