T-LYMPHOCYTE RECEPTOR REPERTOIRE OF INFILTRATING T-LYMPHOCYTES INTO NOD MOUSE PANCREAS

被引:48
作者
MAEDA, T
SUMIDA, T [1 ]
KURASAWA, K
TOMIOKA, H
ITOH, I
YOSHIDA, S
KOIKE, T
机构
[1] CHIBA UNIV,SCH MED,DEPT INTERNAL MED 2,1-8-1 INOHANA,CHIBA 280,JAPAN
[2] CHIBA UNIV,SCH MED,CTR LAB ANIM,CHIBA 280,JAPAN
关键词
D O I
10.2337/diabetes.40.12.1580
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study analyzed T-lymphocyte-receptor V-beta genes of infiltrating lymphocytes into the pancreases of 12-to 16-wk-old NOD mice with severe insulitis and 5-wk-old mice with mild insulitis by the quantitative polymerase chain reaction method. The V-beta transcripts on infiltrating T lymphocytes into pancreases with severe insulitis in older NOD mice were diverse. In contrast, the V-beta-11 gene transcript was predominantly expressed on T lymphocytes in the pancreas in younger NOD mice with mild insulitis, suggesting the possible role of V-beta-11+ T lymphocytes in triggering insulitis in this species.
引用
收藏
页码:1580 / 1585
页数:6
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