THE MURINE MHC ENCODES A MAMMALIAN HOMOLOG OF BACTERIAL RIBOSOMAL-PROTEIN S13

被引：14

作者：

MACMURRAY, AJ

SHIN, HS

机构：

[1] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

MAMMALIAN GENOME | 1992年 / 2卷 / 02期

关键词：

D O I：

10.1007/BF00353855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mouse major histocompatibility complex (MHC) contains many genes in addition to the classical immune response genes. We have screened overlapping cosmid clones covering 170 kb of the H-2K region for genes expressed in embryonal carcinoma (EC) cells. The Ke-3 gene (Abe et al. 1988) found in this region was further studied by Southern, Northern, and sequence analysis. It is an expressed, intron-containing locus encoding a mouse homolog of the bacterial ribosomal protein S13. This is the first non-organelle S13 homolog identified in metazoans, and its genomic location has been determined precisely.

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页码：87 / 95

页数：9

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