A RANDOMIZED, PROSPECTIVE, DOUBLE-BLINDED TRIAL OF CYCLOSPORINE VS OG37-325 IN CADAVERIC RENAL-TRANSPLANTATION - A PRELIMINARY-REPORT

被引:21
作者
HENRY, ML
TESI, RJ
ELKHAMMAS, EA
FERGUSON, RM
BOLLINGER
LEICHTMAN
SCHROEDER
STARZL
机构
[1] Division of Transplantation, Department of Surgery, Ohio State Univ. College of Medicine, Columbus
关键词
D O I
10.1097/00007890-199304000-00012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The efficacy of cyclosporine is documented, but it has side effects that are troublesome. Another compound, OG37-325, has been identified that appears to have similar efficacy, but less nephrotoxicity. This study was designed to address the benefits and toxicities of cyclosporine and OG37-325 in a prospective, randomized, double-blinded trial in cadaveric renal transplant recipients. The preliminary results demonstrate similar outcomes in terms of patient and graft survival, but suggest less nephrotoxicity in the OG37-325-treated patients. longer follow-up will delineate the utility of OG37-325 in solid-organ transplantation.
引用
收藏
页码:748 / 752
页数:5
相关论文
共 20 条
[1]  
ADAMS M, 1992, AM SOC TRANSPLANT PH, V11, P71
[2]   CYCLOSPORINE NEPHROTOXICITY [J].
BENNETT, WM ;
PULLIAM, JP .
ANNALS OF INTERNAL MEDICINE, 1983, 99 (06) :851-854
[3]   MACROPHAGES AS TARGETS FOR INHIBITION BY CYCLOSPORINE [J].
BENSON, A ;
ZIEGLER, HK .
TRANSPLANTATION, 1989, 47 (04) :696-703
[4]   HYPERTENSION AFTER RENAL-TRANSPLANTATION - A COMPARISON OF CYCLOSPORINE AND CONVENTIONAL IMMUNOSUPPRESSION [J].
CHAPMAN, JR ;
MARCEN, R ;
ARIAS, M ;
RAINE, AEG ;
DUNNILL, MS ;
MORRIS, PJ .
TRANSPLANTATION, 1987, 43 (06) :860-864
[5]  
COHEN SL, 1987, TRANSPLANT P, V19, P1829
[6]  
GELFAND EW, 1987, J IMMUNOL, V138, P1115
[7]   A COMPARISON OF CYCLOSPORINE-A AND NVA2-CYCLOSOPORINE (CYCLOSPORINE-G) IN A RAT RENAL-ALLOGRAFT MODEL [J].
GRANT, D ;
ZHONG, R ;
STILLER, C ;
WALLACE, C ;
KEOWN, P ;
DUFF, J .
TRANSPLANTATION, 1987, 44 (01) :9-12
[8]  
HAGASHI A, 1950, J LAB CLIN MED, V35, P475
[9]   BENEFICIAL-EFFECTS OF CYCLOSPORINE COMPARED WITH AZATHIOPRINE IN CADAVERIC RENAL-TRANSPLANTATION [J].
HENRY, ML ;
SOMMER, BG ;
FERGUSON, RM .
AMERICAN JOURNAL OF SURGERY, 1985, 150 (05) :533-536
[10]  
HENRY ML, 1988, TRANSPLANT P, V20, P419