HERPES-SIMPLEX VIRUS THYMIDINE KINASE AND SPECIFIC STAGES OF LATENCY IN MURINE TRIGEMINAL GANGLIA

被引:49
作者
JACOBSON, JG
RUFFNER, KL
KOSZVNENCHAK, M
HWANG, CBC
WOBBE, KK
KNIPE, DM
COEN, DM
机构
[1] HARVARD UNIV, SCH MED, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, COMM VIROL, BOSTON, MA 02115 USA
[3] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA
[4] JAGIELLONIAN UNIV, INST MOLEC BIOL, PL-31007 KRAKOW, POLAND
关键词
D O I
10.1128/JVI.67.11.6903-6908.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
From marker rescue, sequencing, transcript, and latency analyses of the thymidine kinase-negative herpes simplex virus mutant dlsactk and studies using the thymidine kinase inhibitor Ro 31-5140, we infer that the virus-encoded thymidine kinase is required in murine trigeminal ganglia for acute replication and lytic gene expression, for increasing the numbers of cells expressing latency-associated transcripts, and for reactivation from latent infection.
引用
收藏
页码:6903 / 6908
页数:6
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