PERSISTENCE OF POLYOMAVIRUS IN MICE INFECTED AS ADULTS DIFFERS FROM THAT OBSERVED IN MICE INFECTED AS NEWBORNS

被引：21

作者：

BERKE, Z

DALIANIS, T

机构：

[1] KAROLINSKA INST,STOCKHOLM CTY COUNCIL,DEPT CLIN VIROL,MICROBIOL CENT LAB,S-14186 HUDDINGE,SWEDEN

[2] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN VIROL,S-14186 HUDDINGE,SWEDEN

[3] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN VIROL IMMUNOL,S-14186 HUDDINGE,SWEDEN

[4] KAROLINSKA INST,DEPT TUMOR BIOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 07期

关键词：

D O I：

10.1128/JVI.67.7.4369-4371.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

By using the polymerase chain reaction (PCR) technique, a technique more sensitive than Southern analysis, which allows detection of polyomavirus DNA only in newborn and nude adult mice, it has now been possible to monitor the persistence pattern of polyomavirus DNA after infection of normal adult CBA mice for the first time. Viral signs appeared gradually, showing variations in time course and organ distribution between mice, and reached a peak activity after 2 to 3 weeks, when they could be found in bone, heart, gonads, lymph node, and skin, but disappeared by 2 to 5 months. No virus DNA was detected in the kidneys or lungs, which is in contrast to what is observed after infection of newborn mice. This finding suggests that the persistence pattern of polyomavirus is age dependent.

引用

页码：4369 / 4371

页数：3