YY1 IS THE CELLULAR FACTOR SHOWN PREVIOUSLY TO BIND TO REGULATORY REGIONS OF SEVERAL LEAKY-LATE (BETA-GAMMA, GAMMA(L)) GENES OF HERPES-SIMPLEX VIRUS TYPE-1

被引：21

作者：

MILLS, LK

SHI, Y

MILLETTE, RL

机构：

[1] PORTLAND STATE UNIV,DEPT BIOL,PORTLAND,OR 97207

[2] OREGON HLTH SCI UNIV,DEPT MICROBIOL & IMMUNOL,PORTLAND,OR 97201

[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 02期

关键词：

D O I：

10.1128/JVI.68.2.1234-1238.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have recently reported that a cellular factor, the leaky-late binding factor (LBF), binds to sites in a number of leaky-late (beta gamma or gamma(1)) genes of herpes simplex virus type 1 and that an LBF site is essential for maximum viral transactivation of the major capsid protein (VP5) gene. The results of binding competition, partial proteolysis, and monoclonal antibody inhibition assays presented here establish that LBF is identical to the transcription factor YY1. This, along with our previous observations, suggests that YY1 plays a role in herpes simplex virus type 1 gene regulation.

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页码：1234 / 1238

页数：5

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