THE GABRIEL-COLMAN REARRANGEMENT IN BIOLOGICAL-SYSTEMS - DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHTHALIMIDE AND SACCHARIN DERIVATIVES AS POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, CATHEPSIN-G AND PROTEINASE-3

被引：11

作者：

GROUTAS, WC

CHONG, LS

VENKATARAMAN, R

EPP, JB

KUANG, R

HOUSERARCHIELD, N

HOIDAL, JR

机构：

[1] WICHITA STATE UNIV, DEPT CHEM, WICHITA, KS 67260 USA

[2] UNIV UTAH, SCH MED, DIV RESP CRIT CARE & OCCUPAT PULM MED, SALT LAKE CITY, UT 84132 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 02期

关键词：

D O I：

10.1016/0968-0896(95)00013-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.

引用

页码：187 / 193

页数：7

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