EXCHANGE OF PLASMINOGEN ACTIVATOR BETWEEN SOLUTION AND INTIMA

Intimal plasminogen activator depleted by mechanical injury can be restored by soaking the damaged vein in urine plasminogen activator (urokinase). This restoration occurs with little or no change in the urokinase soaking solution's other activities, vasodilation and fibrinolysis. There is some transfer of intimal plasminogen activator into solution enhancing its vasodilation and fibrinolysis. These exchanges between intimal and urine plasminogen activator activities may indicate biological and even molecular similarities between these plasminogen activators. Restoration of depleted intimal plasminogen activator may be important in clinical medicine. © 1979.