HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PHENYLACETIC ACID IN HUMAN PLASMA EXTRACTED WITH ETHYL-ACETATE

被引：8

作者：

KAREGE, F

RUDOLPH, W

机构：

[1] Institutions Universitaires de Psychiatrie, Service de la Recherche Biologique, Psychopharmacologie Clinique, Geneva, 2 Ch. Petit Bel-Air

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 570卷 / 02期

关键词：

D O I：

10.1016/0378-4347(91)80541-J

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper describes a high-performance liquid chromatographic method with ultraviolet detection for measuring plasma phenylacetic acid. This simple and reliable method consists of an acid hydrolysis of conjugated phenylacetic acid before extraction with an organic solvent: washed ethyl acetate saturated in sodium chloride. The recovery of extraction was estimated by internal standardization with phenylpropionic acid, and validated by addition of phenylacetic acid standards. A preliminary application to plasma phenylacetic acid in patients suffering from depression is described.

引用

页码：376 / 381

页数：6

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