NO EFFECT OF SYSTEMIC ADMINISTRATION OF SOMATOMEDIN-C ON BONE REPAIR IN RATS

被引：11

作者：

KIRKEBY, OJ

EKELAND, A

机构：

[1] UNIV OSLO,INST SURG RES,OSLO 3,NORWAY

[2] UNIV OSLO,SOPHIES MINDE ORTHOPED HOSP,OSLO 3,NORWAY

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1990年 / 61卷 / 04期

关键词：

D O I：

10.3109/17453679008993530

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The effect of somatomedin C on the bone repair process was studied in a rat femoral osteotomy. We used continuous systemic administration of human recombinant somatomedin C (110 μg/100 g per day). Radiographic evaluation after 4 weeks showed no effect of somatomedin C on the healing. There was no effect on mechanical strength, and no effect was found on callus vascularization or mineralization. the weight of the callus was slightly reduced in the somatomedin C treated rats. the results were not suggestive of any acceleration with systemic somatomedin C treatment in the early phase of cortical bone repair. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：335 / 338

页数：4

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