ISOLATION OF 24-HYDROPEROXY-24-VINYLCHOLESTEROL AND FUCOSTEROL FROM THE BROWN ALGA TURBINARIA-CONOIDES

被引：20

作者：

SHEU, JH ^{[1
]}

SUNG, PJ ^{[1
]}

机构：

[1] NATL SUN YAT SEN UNIV,INST MARINE BIOL,KAOHSIUNG 804,TAIWAN

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 1991年 / 38卷 / 05期

关键词：

BROWN ALGAE; TURBINARIA-CONOIDES; HYDROPEROXY STEROIDS; SELECTIVE CYTOTOXICITY; MITOGEN;

D O I：

10.1002/jccs.199100084

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly cytotoxic hydroperoxysterol 24-hydroperoxy-24-vinylcholesterol (1) and fucosterol (2) were isolated from the brown alga Turbinaria conoides. Compound (1) was transformed into 29-hydroperoxystigmasta-5,24(28)-dien-3-beta-ol3 in chloroform solution at -5-0-degrees-C in quantitative yield. The latter compound has been shown to exhibit much stronger cytotoxicity toward cultured spleen lymphocytes stimulated by mitogen concanavalin A than toward normal spleen lymphocytes.

引用

页码：501 / 503

页数：3

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