SUPEROXIDE PRODUCTION BY CROHNS-DISEASE NEUTROPHILS

被引：36

作者：

CURRAN, FT ^{[1
]}

ALLAN, RN ^{[1
]}

KEIGHLEY, MRB ^{[1
]}

机构：

[1] GEN HOSP, BIRMINGHAM B4 6NH, W MIDLANDS, ENGLAND

来源：

GUT | 1991年 / 32卷 / 04期

关键词：

D O I：

10.1136/gut.32.4.399

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Neutrophil superoxide anion production was measured in healthy subjects and in patients with quiescent and active Crohn's diseae using superoxide dismutase inhibitable cytochrome C reduction. Three stimuli were used: phorbol 12-myristate 13-acetate (PMA1), phorbol 20-oxo-20-deoxy 12-myristate 13-acetate (PMA2), and Candida albicans in serum. Normal neutrophils produced significantly more superoxide anion than Crohn's disease neutrophils with both PMA1 (mean (SD) 9.6 (2.2) v 8.6 (1.8) nmol/10(6) cells/5 minutes, p = 0.04) and PMA2 (1.8 (0.8) v 0.8 (0.77) nmol/10(6) cells/5 minutes, p = 0.00004). With C albicans in serum, normal and Crohn's disease neutrophils produced similar amounts of superoxide anion (4.4 (1.5) v 4.3 (1.7) nmol/10(6) cells/30 minutes, not significant). Results were independent of disease activity. Superoxide anion production by PMA-stimulated Crohn's disease neutrophils is significantly lower than by normal neutrophils.

引用

页码：399 / 402

页数：4

共 28 条

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