ATTENUATION OF MALARIA INFECTION, PARALYSIS AND LESIONS IN THE CENTRAL-NERVOUS-SYSTEM BY LOW PROTEIN DIETS IN RATS

被引:10
作者
BAKKER, NPM
ELING, WMC
DEGROOT, AMT
SINKELDAM, EJ
LUYKEN, R
机构
[1] TNO,INST TOXICOL & NUTR,POB 360,3700 AJ ZEIST,NETHERLANDS
[2] CATHOLIC UNIV NIJMEGEN,DEPT CYTOL & HISTOL,NIJMEGEN,NETHERLANDS
[3] UNIV AMSTERDAM,FAC MED,DEPT HLTH SCI,AMSTERDAM,NETHERLANDS
关键词
PLASMODIUM-BERGHEI; RODENT MALARIA; DIETARY PROTEIN;
D O I
10.1016/0001-706X(92)90063-4
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Young Wistar rats developed a fulminant infection when inoculated with the rodent malaria parasite Plasmodium berghei. Rats that died during the infection exhibited a progressive paralysis of the extremities. a rapidly decreasing body temperature and minute haemorrhages in the brain. Increasing the level of protein in the diet from 4 to 8 and 16% was accompanied by an increase in morbidity and mortality from 15 to 40 and 90% respectively on day 6 of the infection. Increasing the level of dietary protein also increased the reticulocyte count of the peripheral blood in infected and non-infected rats. The attenuation of the cerebral syndrome in rats fed a diet low in protein may be related to changes in erythropoiesis or to changes in immune reactivity.
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页码:285 / 293
页数:9
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