P-GLYCOPROTEIN TRANSPORTS CORTICOSTERONE AND IS PHOTOAFFINITY-LABELED BY THE STEROID

被引：92

作者：

WOLF, DC

HORWITZ, SB

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOLEC PHARMACOL,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,LIVER RES CTR,BRONX,NY 10461

来源：

INTERNATIONAL JOURNAL OF CANCER | 1992年 / 52卷 / 01期

关键词：

D O I：

10.1002/ijc.2910520125

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multi-drug-resistant cells overproduce a 130-180-kDa integral membrane phosphoglycoprotein known as P-glycoprotein which acts as an energy-dependent drug efflux pump. While P-glycoprotein has been shown to transport hydrophobic anti-tumor drugs out of multi-drug-resistant cells in tissue culture, its endogenous substrates remain unknown. This report shows that H-3-corticosterone can specifically photoaffinity label P-glycoprotein. Furthermore, corticosterone is effluxed from multi-drug-resistant cells by P-glycoprotein. These data suggest that corticosterone may be an endogenous substrate for P-glycoprotein.

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页码：141 / 146

页数：6

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