EFFECT OF PHOSPHATIDYLCHOLINE ON THE FUNCTION OF HUMAN MESOTHELIAL CELLS-INVITRO

被引:8
作者
BREBOROWICZ, A
WITOWSKI, J
KNAPOWSKI, J
SERKES, KD
MARTIS, L
OREOPOULOS, DG
机构
[1] MED ACAD POZNAN,PL-60780 POZNAN,POLAND
[2] UNIV TORONTO,TORONTO M5S 1A1,ONTARIO,CANADA
[3] BAXTER HEALTHCARE CORP,DEERFIELD,IL
来源
NEPHRON | 1993年 / 63卷 / 01期
关键词
MESOTHELIAL CELLS; PHOSPHATIDYLCHOLINE; CYTOTOXICITY;
D O I
10.1159/000187138
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We tested the hypothesis that phosphatidylcholine (PC) molecules present in the dialysis solution may interact with the mesothelial cell membrane and modify its function. In vitro experiments were performed on human mesothelial cells (HMC) in culture. PC decreased proliferation of HMC when used at concentrations of 200 mg/l and higher. PC was also cytotoxic to HMC as measured by the release of lactate dehydrogenase from their cytosol. Cells exposed to PC had a diminished capacity for taking up Rb-86 from medium. PC decreased the fibrinolytic properties of HMC and increased their procoagulant activity. Our results suggest that the positive short-term effect of the addition of PC to the dialysis solution (i.e., an increase in ultrafiltration) may be over-shadowed by its deleterious action on HMC membrane.
引用
收藏
页码:15 / 20
页数:6
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